human VSIG4 recombinant protein, 500 μg. Cat# 5008

Description

Our CHO cell expressed human VSIG4 is a recombinant protein that contains VSIG4 (399 a.a.) and human IgG1 Fc. According to https://www.ncbi.nlm.nih.gov/gene/11326, the v-set and immunoglobulin-domain containing protein 4 “is structurally related to the B7 family of immune regulatory proteins. The encoded protein may be a negative regulator of T-cell responses. This protein is also a receptor for the complement component 3 fragments C3b and iC3b.” The expression of VSIG4 is restricted to tissue macrophages. VSIG4 plays a pivotal role in clearing C3-opsonized pathogens and their byproducts from the circulation. Vogt and co-authors reported that “VSIG4 is a strong negative regulator of murine and human T cell proliferation and IL-2 production. Administration to mice of soluble VSIG4-Ig fusion molecules reduced the induction of T cell responses in vivo and inhibited the production of Th cell–dependent IgG responses. ” VSIG4 negatively regulates macrophage activation by reprogramming mitochondrial pyruvate metabolism (Li., et al).

Price: $795 / 500 μg.

Reference

Vogt, L., et al. VSIG4, a B7 family–related protein, is a negative regulator of T cell activation. J Clin Invest. 2006;116(10):2817-2826. https://doi.org/10.1172/JCI25673.

Li, J., Diao, B., Guo, S. et al. VSIG4 inhibits proinflammatory macrophage activation by reprogramming mitochondrial pyruvate metabolism. Nat Commun 8, 1322 (2017). https://doi.org/10.1038/s41467-017-01327-4